The hands down best practice for cleaning up after your toddler eats is to have a package of baby wipes at the table at all times! I don't know why I didn't think of it sooner but it has been so helpful.
Also at my meal time table are two circular floor mats under each child's seat. These are inexpensive, yet priceless and have literally saved my floor from spilled foods and beverages. They also both use booster seats as opposed to highchairs. I have found them to be better overall and now that my son doesn't need the tray anymore I am able to alternate the trays in the dishwasher on a regular basis.
You may also be interested in reading:
Jeep Protective Floor Mat
When It's Time To Wean
Operation: Clean Out Pantry
Making Baby Food: Part 1